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Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis
المؤلفون المشاركون
Misra, Suniti
Hascall, Vincent C.
Atanelishvili, Ilia
Moreno Rodriguez, Ricardo
Markwald, Roger R.
Ghatak, Shibnath
Mack, Judith A.
Maytin, Edward V.
المصدر
International Journal of Cell Biology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-10
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
A wound is a type of injury that damages living tissues.
In this review, we will be referring mainly to healing responses in the organs including skin and the lungs.
Fibrosis is a process of dysregulated extracellular matrix (ECM) production that leads to a dense and functionally abnormal connective tissue compartment (dermis).
In tissues such as the skin, the repair of the dermis after wounding requires not only the fibroblasts that produce the ECM molecules, but also the overlying epithelial layer (keratinocytes), the endothelial cells, and smooth muscle cells of the blood vessel and white blood cells such as neutrophils and macrophages, which together orchestrate the cytokine-mediated signaling and paracrine interactions that are required to regulate the proper extent and timing of the repair process.
This review will focus on the importance of extracellular molecules in the microenvironment, primarily the proteoglycans and glycosaminoglycan hyaluronan, and their roles in wound healing.
First, we will briefly summarize the physiological, cellular, and biochemical elements of wound healing, including the importance of cytokine cross-talk between cell types.
Second, we will discuss the role of proteoglycans and hyaluronan in regulating these processes.
Finally, approaches that utilize these concepts as potential therapies for fibrosis are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghatak, Shibnath& Maytin, Edward V.& Mack, Judith A.& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo…[et al.]. 2015. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghatak, Shibnath…[et al.]. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghatak, Shibnath& Maytin, Edward V.& Mack, Judith A.& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo…[et al.]. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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