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Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis
Joint Authors
Misra, Suniti
Hascall, Vincent C.
Atanelishvili, Ilia
Moreno Rodriguez, Ricardo
Markwald, Roger R.
Ghatak, Shibnath
Mack, Judith A.
Maytin, Edward V.
Source
International Journal of Cell Biology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
A wound is a type of injury that damages living tissues.
In this review, we will be referring mainly to healing responses in the organs including skin and the lungs.
Fibrosis is a process of dysregulated extracellular matrix (ECM) production that leads to a dense and functionally abnormal connective tissue compartment (dermis).
In tissues such as the skin, the repair of the dermis after wounding requires not only the fibroblasts that produce the ECM molecules, but also the overlying epithelial layer (keratinocytes), the endothelial cells, and smooth muscle cells of the blood vessel and white blood cells such as neutrophils and macrophages, which together orchestrate the cytokine-mediated signaling and paracrine interactions that are required to regulate the proper extent and timing of the repair process.
This review will focus on the importance of extracellular molecules in the microenvironment, primarily the proteoglycans and glycosaminoglycan hyaluronan, and their roles in wound healing.
First, we will briefly summarize the physiological, cellular, and biochemical elements of wound healing, including the importance of cytokine cross-talk between cell types.
Second, we will discuss the role of proteoglycans and hyaluronan in regulating these processes.
Finally, approaches that utilize these concepts as potential therapies for fibrosis are discussed.
American Psychological Association (APA)
Ghatak, Shibnath& Maytin, Edward V.& Mack, Judith A.& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo…[et al.]. 2015. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
Modern Language Association (MLA)
Ghatak, Shibnath…[et al.]. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
American Medical Association (AMA)
Ghatak, Shibnath& Maytin, Edward V.& Mack, Judith A.& Hascall, Vincent C.& Atanelishvili, Ilia& Moreno Rodriguez, Ricardo…[et al.]. Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis. International Journal of Cell Biology. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1065360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065360