Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
المؤلفون المشاركون
Valančiūtė, Angelija
Mozuraite, Raminta
Juodziukyniene, Nomeda
Uleckiene, Saule
Matusevičius, Paulius
Didžiapetrienė, Janina
Stakišaitis, Donatas
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated.
BALB/c mice ( n = 60 ; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control.
In the same groups, ovariectomized female mice ( n = 60 ) were investigated.
Urethane was given intraperitoneally, with a total dose of 50 mg/mouse.
In NaVP-treated mice groups, 0.4% aqueous solution of NaVP was offered to mice ad libitum.
The duration of the experiment was 6 months.
The number of tumors per mouse in ovariectomized mice and in those treated with urethane and NaVP was significantly higher than in mice treated with urethane only ( 8.29 ± 0.58 versus 6.0 ± 0.63 , p < 0.02 ).
No significant difference in the number of tumors per mouse was revealed while comparing the nonovariectomized urethane- and urethane-NaVP-treated groups ( p = 0.13 ).
A significant decrease of adenocarcinoma number in ovariectomized mice treated with a urethane-NaVP as compared with ovariectomized mice treated with urethane only was found ( p = 0.031 ).
NaVP together with low estrogen may have a protective effect on the malignization of adenomas in ovariectomized mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stakišaitis, Donatas& Mozuraite, Raminta& Juodziukyniene, Nomeda& Didžiapetrienė, Janina& Uleckiene, Saule& Matusevičius, Paulius…[et al.]. 2015. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stakišaitis, Donatas…[et al.]. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stakišaitis, Donatas& Mozuraite, Raminta& Juodziukyniene, Nomeda& Didžiapetrienė, Janina& Uleckiene, Saule& Matusevičius, Paulius…[et al.]. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر