Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
Joint Authors
Valančiūtė, Angelija
Mozuraite, Raminta
Juodziukyniene, Nomeda
Uleckiene, Saule
Matusevičius, Paulius
Didžiapetrienė, Janina
Stakišaitis, Donatas
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated.
BALB/c mice ( n = 60 ; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control.
In the same groups, ovariectomized female mice ( n = 60 ) were investigated.
Urethane was given intraperitoneally, with a total dose of 50 mg/mouse.
In NaVP-treated mice groups, 0.4% aqueous solution of NaVP was offered to mice ad libitum.
The duration of the experiment was 6 months.
The number of tumors per mouse in ovariectomized mice and in those treated with urethane and NaVP was significantly higher than in mice treated with urethane only ( 8.29 ± 0.58 versus 6.0 ± 0.63 , p < 0.02 ).
No significant difference in the number of tumors per mouse was revealed while comparing the nonovariectomized urethane- and urethane-NaVP-treated groups ( p = 0.13 ).
A significant decrease of adenocarcinoma number in ovariectomized mice treated with a urethane-NaVP as compared with ovariectomized mice treated with urethane only was found ( p = 0.031 ).
NaVP together with low estrogen may have a protective effect on the malignization of adenomas in ovariectomized mice.
American Psychological Association (APA)
Stakišaitis, Donatas& Mozuraite, Raminta& Juodziukyniene, Nomeda& Didžiapetrienė, Janina& Uleckiene, Saule& Matusevičius, Paulius…[et al.]. 2015. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
Modern Language Association (MLA)
Stakišaitis, Donatas…[et al.]. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
American Medical Association (AMA)
Stakišaitis, Donatas& Mozuraite, Raminta& Juodziukyniene, Nomeda& Didžiapetrienė, Janina& Uleckiene, Saule& Matusevičius, Paulius…[et al.]. Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065596