Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism
المؤلفون المشاركون
Liu, Minghua
Hu, Yanyan
Li, Guimei
Hu, Wenwen
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
The follow-up of GH levels in short-stature children with pituitary hyperplasia secondary to primary hypothyroidism (PPH) is reported in a few cases.
We aimed to observe changes in GH secretion in short-stature children with PPH.
Methods.
A total of 11 short-stature children with PPH accompanied by low GH levels were included.
They received levothyroxine therapy after diagnosis.
Their thyroid hormones, IGF-1, PRL, and pituitary height were measured at baseline and 3 months after therapy.
GH stimulation tests were performed at baseline and after regression of thyroid hormones and pituitary.
Results.
At baseline, they had decreased GH peak and FT3 and FT4 levels and elevated TSH levels.
Decreased IGF-1 levels were found in seven children.
Elevated PRL levels and positive thyroid antibodies were found in 10 children.
The mean pituitary height was 14.3±3.8 mm.
After 3 months, FT3, FT4, and IGF-1 levels were significantly increased (all p<0.01), and values of TSH, PRL, and pituitary height were significantly decreased (all p<0.001).
After 6 months, pituitary hyperplasia completely regressed.
GH levels returned to normal in nine children and were still low in two children.
Conclusion.
GH secretion can be resolved in most short-stature children with PPH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Minghua& Hu, Yanyan& Li, Guimei& Hu, Wenwen. 2015. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Minghua…[et al.]. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Minghua& Hu, Yanyan& Li, Guimei& Hu, Wenwen. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065617
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر