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Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism
Joint Authors
Liu, Minghua
Hu, Yanyan
Li, Guimei
Hu, Wenwen
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The follow-up of GH levels in short-stature children with pituitary hyperplasia secondary to primary hypothyroidism (PPH) is reported in a few cases.
We aimed to observe changes in GH secretion in short-stature children with PPH.
Methods.
A total of 11 short-stature children with PPH accompanied by low GH levels were included.
They received levothyroxine therapy after diagnosis.
Their thyroid hormones, IGF-1, PRL, and pituitary height were measured at baseline and 3 months after therapy.
GH stimulation tests were performed at baseline and after regression of thyroid hormones and pituitary.
Results.
At baseline, they had decreased GH peak and FT3 and FT4 levels and elevated TSH levels.
Decreased IGF-1 levels were found in seven children.
Elevated PRL levels and positive thyroid antibodies were found in 10 children.
The mean pituitary height was 14.3±3.8 mm.
After 3 months, FT3, FT4, and IGF-1 levels were significantly increased (all p<0.01), and values of TSH, PRL, and pituitary height were significantly decreased (all p<0.001).
After 6 months, pituitary hyperplasia completely regressed.
GH levels returned to normal in nine children and were still low in two children.
Conclusion.
GH secretion can be resolved in most short-stature children with PPH.
American Psychological Association (APA)
Liu, Minghua& Hu, Yanyan& Li, Guimei& Hu, Wenwen. 2015. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
Modern Language Association (MLA)
Liu, Minghua…[et al.]. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
American Medical Association (AMA)
Liu, Minghua& Hu, Yanyan& Li, Guimei& Hu, Wenwen. Low Growth Hormone Levels in Short-Stature Children with Pituitary Hyperplasia Secondary to Primary Hypothyroidism. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065617