High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis
المؤلفون المشاركون
Choi, Yuri
Roh, Jaesook
Park, Minji
Choi, Hyeonhae
Yim, Ju-Yearn
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Prenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring.
Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation.
This study investigated the impact of high doses of caffeine on the testes of prepubertal male rats.
A total of 45 immature male rats were divided randomly into three groups: a control group and 2 groups fed 120 and 180 mg/kg/day of caffeine, respectively, via the stomach for 4 weeks.
Caffeine caused a significant decrease in body weight gain, accompanied by proportional decreases in lean body mass and body fat.
The caffeine-fed animals had smaller and lighter testes than those of the control that were accompanied by negative influences on the histologic parameters of the testes.
In addition, stimulated-testosterone ex vivo production was reduced in Leydig cells retrieved from the caffeine-fed animals.
Our results demonstrate that peripubertal caffeine consumption can interfere with the maturation and function of the testis, possibly by interrupting endogenous testosterone secretion and reducing the sensitivity of Leydig cells to gonadotrophic stimulation.
In addition, we confirmed that pubertal administration of caffeine reduced testis growth and altered testis histomorphology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Minji& Choi, Yuri& Choi, Hyeonhae& Yim, Ju-Yearn& Roh, Jaesook. 2015. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Minji…[et al.]. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Minji& Choi, Yuri& Choi, Hyeonhae& Yim, Ju-Yearn& Roh, Jaesook. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065661
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر