High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis
Joint Authors
Choi, Yuri
Roh, Jaesook
Park, Minji
Choi, Hyeonhae
Yim, Ju-Yearn
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Prenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring.
Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation.
This study investigated the impact of high doses of caffeine on the testes of prepubertal male rats.
A total of 45 immature male rats were divided randomly into three groups: a control group and 2 groups fed 120 and 180 mg/kg/day of caffeine, respectively, via the stomach for 4 weeks.
Caffeine caused a significant decrease in body weight gain, accompanied by proportional decreases in lean body mass and body fat.
The caffeine-fed animals had smaller and lighter testes than those of the control that were accompanied by negative influences on the histologic parameters of the testes.
In addition, stimulated-testosterone ex vivo production was reduced in Leydig cells retrieved from the caffeine-fed animals.
Our results demonstrate that peripubertal caffeine consumption can interfere with the maturation and function of the testis, possibly by interrupting endogenous testosterone secretion and reducing the sensitivity of Leydig cells to gonadotrophic stimulation.
In addition, we confirmed that pubertal administration of caffeine reduced testis growth and altered testis histomorphology.
American Psychological Association (APA)
Park, Minji& Choi, Yuri& Choi, Hyeonhae& Yim, Ju-Yearn& Roh, Jaesook. 2015. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
Modern Language Association (MLA)
Park, Minji…[et al.]. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
American Medical Association (AMA)
Park, Minji& Choi, Yuri& Choi, Hyeonhae& Yim, Ju-Yearn& Roh, Jaesook. High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065661