Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients
المؤلفون المشاركون
Radhakrishnan, Vinodh Kumar
Hernandez, Lorraine Christine
Anderson, Kendra
Tan, Qianwei
De León, Marino
De León, Daisy D.
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
African American women suffer higher incidence and mortality of triple negative breast cancer (TNBC) than Caucasian women.
TNBC is very aggressive, causing the worst clinical outcome.
We previously demonstrated that tumors from these patients express high IGF-II and exhibit high activation of the IGF signaling pathways.
IGF-II gene expression is imprinted (monoallelic), promotes tumor progression, and metastasis and regulates Survivin, a TNBC prognostic marker.
Since BC mortality has increased among young Vietnamese women, we analyzed 48 (paired) TNBC samples from Vietnamese patients to assess IGF-II expression.
We analyzed all samples by qrtPCR for identification of IGF-II heterozygosity and to determine allelic expression of the IGF-II gene.
We also analyzed the tissues for proIGF-II and Survivin by RT-PCR and Western blotting.
A total of 28 samples displayed IGF-II heterozygosity of which 78% were biallelic.
Tumors with biallelic IGF-II gene expression exhibited the highest levels of proIGF-II and Survivin.
Although 100% of these tissues corresponding normal samples were biallelic, they expressed significantly lower levels of or no proIGF-II and Survivin.
Thus, IGF-II biallelic gene expression is differentially regulated in normal versus tumor tissues.
We propose that intratumoral proIGF-II is dependent on the IGF-II gene imprinting status and it will promote a more aggressive TNBC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Radhakrishnan, Vinodh Kumar& Hernandez, Lorraine Christine& Anderson, Kendra& Tan, Qianwei& De León, Marino& De León, Daisy D.. 2015. Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Radhakrishnan, Vinodh Kumar…[et al.]. Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients. International Journal of Endocrinology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1065688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Radhakrishnan, Vinodh Kumar& Hernandez, Lorraine Christine& Anderson, Kendra& Tan, Qianwei& De León, Marino& De León, Daisy D.. Expression of Intratumoral IGF-II Is Regulated by the Gene Imprinting Status in Triple Negative Breast Cancer from Vietnamese Patients. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1065688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر