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The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, AdiponectinLeptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males
المؤلفون المشاركون
Lai, Wen-Ter
Cheng, Kai-Hung
Liu, Chia-Chu
Huang, Chun-Nung
Lee, Yung-Chin
Chu, Chih-Sheng
Chang, Chu-Fen
Huang, Shu-Pin
Kuo, Po-Lin
Hsi, Edward
Bao, Bo-Ying
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD).
Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.
In vitamin D3 metabolism, the vitamin D3 25-hydroxylase (CYP27A1) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are two key enzymes.
This study aimed to examine the influence of vitamin D3 CYP27 single nucleotide polymorphisms (SNPs) on adipocytokines and MetS.
Cross-sectional data and DNA samples were collected from male volunteers ( n = 649 , age: 55.7 ± 4.7 years).
Two tagging SNPs, CYP27A1 rs4674344 and CYP27B1 rs10877012, were selected from the HapMap project.
MetS was significantly associated with the CYP27A1 rs4674344 SNP ( P = 0.04 ) and the ratio of adiponectin/leptin (A/L ratio) was most correlated to the CYP27A1 rs4674344 SNP, appearing to be significantly lower in T-carriers than in AA subjects (3.7 ± 4.0 versus 5.1 ± 6.0, P = 0.001 ) and significantly negatively associated after adjustment.
For each MetS component associated with the CYP27A1 rs4674344 SNP, the A/L ratios were significantly negative in preclinical stage (condition not meeting the individual criteria), except the blood pressure.
In conclusion, CYP27A1 rs4674344 SNP, A/L ratio, and MetS are significantly associated and T-carriers might have a higher risk of developing MetS due to low A/L ratios in the preclinical stage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Kai-Hung& Hsi, Edward& Liu, Chia-Chu& Huang, Chun-Nung& Lee, Yung-Chin& Chu, Chih-Sheng…[et al.]. 2015. The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, AdiponectinLeptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Kai-Hung…[et al.]. The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, AdiponectinLeptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males. International Journal of Endocrinology No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1065772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Kai-Hung& Hsi, Edward& Liu, Chia-Chu& Huang, Chun-Nung& Lee, Yung-Chin& Chu, Chih-Sheng…[et al.]. The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, AdiponectinLeptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1065772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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