The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, AdiponectinLeptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males

Abstract EN

Metabolic syndrome (MetS) confers increased risks of cardiovascular disease (CVD).

Both vitamin D3 and adipocytokines (especially adiponectin and leptin) have a great impact on CVD and MetS.

In vitamin D3 metabolism, the vitamin D3 25-hydroxylase (CYP27A1) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) are two key enzymes.

This study aimed to examine the influence of vitamin D3 CYP27 single nucleotide polymorphisms (SNPs) on adipocytokines and MetS.

Cross-sectional data and DNA samples were collected from male volunteers ( n = 649 , age: 55.7 ± 4.7 years).

Two tagging SNPs, CYP27A1 rs4674344 and CYP27B1 rs10877012, were selected from the HapMap project.

MetS was significantly associated with the CYP27A1 rs4674344 SNP ( P = 0.04 ) and the ratio of adiponectin/leptin (A/L ratio) was most correlated to the CYP27A1 rs4674344 SNP, appearing to be significantly lower in T-carriers than in AA subjects (3.7 ± 4.0 versus 5.1 ± 6.0, P = 0.001 ) and significantly negatively associated after adjustment.

For each MetS component associated with the CYP27A1 rs4674344 SNP, the A/L ratios were significantly negative in preclinical stage (condition not meeting the individual criteria), except the blood pressure.

In conclusion, CYP27A1 rs4674344 SNP, A/L ratio, and MetS are significantly associated and T-carriers might have a higher risk of developing MetS due to low A/L ratios in the preclinical stage.