Treatment of Prolactinomas in Low-Income Countries
المؤلفون المشاركون
Kruljac, Ivan
Kirigin, Lora Stanka
Strinović, Mateja
Marinković, Jelena
Pećina, Hrvoje Ivan
Čerina, Vatroslav
Stipić, Darko
Vrkljan, Milan
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
In low-income countries, prolactinomas are difficult to manage with dopamine agonists (DA).
We compared the effectiveness of DA in microprolactinomas as a first line treatment and as adjuvant therapy for residual macroprolactinomas treated surgically.
Methods.
Our retrospective study analyzed 78 patients, 38 with microprolactinomas and 40 with macroprolactinomas.
Microprolactinomas were treated with DA.
Macroprolactinomas were treated with microsurgical or endoscopic adenomectomies and adjuvant DA.
Surgical remission was defined as normoprolactinemia three months postoperatively, and long-term remission as normoprolactinemia at the last control.
Results.
Surgical remission was achieved in 9 patients (23%).
Postsurgical tumor mass was reduced by 50% (34–68).
Residual macroprolactinoma size was greater than microprolactinoma size prior to treatment (10 mm versus 4 mm, P < 0.001 ).
Both groups received similar doses of DA.
Long-term remission occurred in 68% of microprolactinomas and 43% of macroprolactinomas ( P = 0.102 ).
Prolactin (PRL) levels at the last control were similar in both groups (23.1 versus 32.9 mcg/L, P = 0.347 ).
Conclusion.
Comparable remission rates and PRL levels were reached in microprolactinomas and macroprolactinomas using similar doses of DA.
Although complete tumor resection is the goal of surgery, our study suggests that even partial surgical removal has a role in treatment of prolactinomas since it may enhance the response to DA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kruljac, Ivan& Kirigin, Lora Stanka& Strinović, Mateja& Marinković, Jelena& Pećina, Hrvoje Ivan& Čerina, Vatroslav…[et al.]. 2015. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kruljac, Ivan…[et al.]. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kruljac, Ivan& Kirigin, Lora Stanka& Strinović, Mateja& Marinković, Jelena& Pećina, Hrvoje Ivan& Čerina, Vatroslav…[et al.]. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر