Treatment of Prolactinomas in Low-Income Countries
Joint Authors
Kruljac, Ivan
Kirigin, Lora Stanka
Strinović, Mateja
Marinković, Jelena
Pećina, Hrvoje Ivan
Čerina, Vatroslav
Stipić, Darko
Vrkljan, Milan
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
In low-income countries, prolactinomas are difficult to manage with dopamine agonists (DA).
We compared the effectiveness of DA in microprolactinomas as a first line treatment and as adjuvant therapy for residual macroprolactinomas treated surgically.
Methods.
Our retrospective study analyzed 78 patients, 38 with microprolactinomas and 40 with macroprolactinomas.
Microprolactinomas were treated with DA.
Macroprolactinomas were treated with microsurgical or endoscopic adenomectomies and adjuvant DA.
Surgical remission was defined as normoprolactinemia three months postoperatively, and long-term remission as normoprolactinemia at the last control.
Results.
Surgical remission was achieved in 9 patients (23%).
Postsurgical tumor mass was reduced by 50% (34–68).
Residual macroprolactinoma size was greater than microprolactinoma size prior to treatment (10 mm versus 4 mm, P < 0.001 ).
Both groups received similar doses of DA.
Long-term remission occurred in 68% of microprolactinomas and 43% of macroprolactinomas ( P = 0.102 ).
Prolactin (PRL) levels at the last control were similar in both groups (23.1 versus 32.9 mcg/L, P = 0.347 ).
Conclusion.
Comparable remission rates and PRL levels were reached in microprolactinomas and macroprolactinomas using similar doses of DA.
Although complete tumor resection is the goal of surgery, our study suggests that even partial surgical removal has a role in treatment of prolactinomas since it may enhance the response to DA.
American Psychological Association (APA)
Kruljac, Ivan& Kirigin, Lora Stanka& Strinović, Mateja& Marinković, Jelena& Pećina, Hrvoje Ivan& Čerina, Vatroslav…[et al.]. 2015. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
Modern Language Association (MLA)
Kruljac, Ivan…[et al.]. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
American Medical Association (AMA)
Kruljac, Ivan& Kirigin, Lora Stanka& Strinović, Mateja& Marinković, Jelena& Pećina, Hrvoje Ivan& Čerina, Vatroslav…[et al.]. Treatment of Prolactinomas in Low-Income Countries. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1065787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065787