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Tumor-Associated Mast Cells in Thyroid Cancer
المؤلفون المشاركون
Visciano, Carla
Prevete, Nella
Liotti, Federica
Marone, Gianni
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies.
Among the different cell populations that infiltrate cancer stroma, mast cells (MCs) can influence several aspects of tumor biology, including tumor development and progression, angiogenesis, lymphangiogenesis, and tissue remodelling.
Thyroid cancer (TC), the most frequent neoplasia of the endocrine system, is characterized by a MC infiltrate, whose density correlates with extrathyroidal extension and invasiveness.
Recent evidence suggests the occurrence of epithelial-to-mesenchymal transition (EMT) and stemness in human TC.
The precise role of immune cells and their mediators responsible for these features in TC remains unknown.
Here, we review the relevance of MC-derived mediators (e.g., the chemokines CXCL1/GRO-α, CXCL10/IP-10, and CXCL8/IL-8) in the context of TC.
CXCL1/GRO-α and CXCL10/IP-10 appear to be involved in the stimulation of cell proliferation, while CXCL8/IL-8 participates in the acquisition of TC malignant traits through its ability to induce/enhance the EMT and stem-like features of TC cells.
The inhibition of chemokine signaling may offer novel therapeutic approaches for the treatment of refractory forms of TC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Visciano, Carla& Prevete, Nella& Liotti, Federica& Marone, Gianni. 2015. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Visciano, Carla…[et al.]. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Visciano, Carla& Prevete, Nella& Liotti, Federica& Marone, Gianni. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065789
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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