Tumor-Associated Mast Cells in Thyroid Cancer
Joint Authors
Visciano, Carla
Prevete, Nella
Liotti, Federica
Marone, Gianni
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is compelling evidence that the tumor microenvironment plays a major role in mediating aggressive features of cancer cells, including invasive capacity and resistance to conventional and novel therapies.
Among the different cell populations that infiltrate cancer stroma, mast cells (MCs) can influence several aspects of tumor biology, including tumor development and progression, angiogenesis, lymphangiogenesis, and tissue remodelling.
Thyroid cancer (TC), the most frequent neoplasia of the endocrine system, is characterized by a MC infiltrate, whose density correlates with extrathyroidal extension and invasiveness.
Recent evidence suggests the occurrence of epithelial-to-mesenchymal transition (EMT) and stemness in human TC.
The precise role of immune cells and their mediators responsible for these features in TC remains unknown.
Here, we review the relevance of MC-derived mediators (e.g., the chemokines CXCL1/GRO-α, CXCL10/IP-10, and CXCL8/IL-8) in the context of TC.
CXCL1/GRO-α and CXCL10/IP-10 appear to be involved in the stimulation of cell proliferation, while CXCL8/IL-8 participates in the acquisition of TC malignant traits through its ability to induce/enhance the EMT and stem-like features of TC cells.
The inhibition of chemokine signaling may offer novel therapeutic approaches for the treatment of refractory forms of TC.
American Psychological Association (APA)
Visciano, Carla& Prevete, Nella& Liotti, Federica& Marone, Gianni. 2015. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
Modern Language Association (MLA)
Visciano, Carla…[et al.]. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
American Medical Association (AMA)
Visciano, Carla& Prevete, Nella& Liotti, Federica& Marone, Gianni. Tumor-Associated Mast Cells in Thyroid Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065789