Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease
المؤلفون المشاركون
Buemi, Michele
Santoro, Domenico
Lucisano, Silvia
Arena, Adriana
Stassi, Giovanna
Iannello, Daniela
Montalto, Gaetano
Romeo, Adolfo
Costantino, Giuseppe
Lupica, Rosaria
Cernaro, Valeria
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro.
Methods.
40 patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism and 40 healthy subjects were enrolled.
Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic and urinary NGAL, and 24 h albuminuria and proteinuria were measured before and 24 h after an intravenous bolus of paricalcitol (5 mcg).
Human peripheral blood mononuclear cells were isolated and stimulated with phytohaemagglutinin.
NGAL, IL-1β, IL-17, IL-6, TNF-α, and IFN-γ were measured in the culture medium and in the 24 h urine collection.
Results.
25(OH)-vitamin D was lower in CKD than in controls ( p < 0.0001 ), while inflammatory markers were higher in CKD group ( p < 0.0001 ).
In vivo and in vitro studies showed a downregulation of NGAL, IL-17, IL-6, IL-1β, TNF-α, and IFN-γ after paricalcitol administration ( p < 0.0001 ).
Conclusions.
25(OH)-vitamin D regulates immune and inflammatory processes.
Further studies are needed to confirm these data in order to improve the treatment of CKD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lucisano, Silvia& Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Montalto, Gaetano& Romeo, Adolfo…[et al.]. 2015. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lucisano, Silvia…[et al.]. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lucisano, Silvia& Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Montalto, Gaetano& Romeo, Adolfo…[et al.]. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر