Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease
Joint Authors
Buemi, Michele
Santoro, Domenico
Lucisano, Silvia
Arena, Adriana
Stassi, Giovanna
Iannello, Daniela
Montalto, Gaetano
Romeo, Adolfo
Costantino, Giuseppe
Lupica, Rosaria
Cernaro, Valeria
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The aim was to highlight the existence of a relationship between vitamin D deficiency, chronic inflammation, and proteinuria, by measuring neutrophil gelatinase associated lipocalin (NGAL) and common inflammatory markers after administration of paricalcitol, a vitamin D analog, in vivo and in vitro.
Methods.
40 patients with end-stage chronic kidney disease (CKD) and secondary hyperparathyroidism and 40 healthy subjects were enrolled.
Serum calcium, phosphorus, 25(OH)-vitamin D, parathyroid hormone (PTH), erythrocyte sedimentation rate, high-sensitivity C-reactive protein, interleukin- (IL-) 17, IL-6, IL-1β, interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), plasmatic and urinary NGAL, and 24 h albuminuria and proteinuria were measured before and 24 h after an intravenous bolus of paricalcitol (5 mcg).
Human peripheral blood mononuclear cells were isolated and stimulated with phytohaemagglutinin.
NGAL, IL-1β, IL-17, IL-6, TNF-α, and IFN-γ were measured in the culture medium and in the 24 h urine collection.
Results.
25(OH)-vitamin D was lower in CKD than in controls ( p < 0.0001 ), while inflammatory markers were higher in CKD group ( p < 0.0001 ).
In vivo and in vitro studies showed a downregulation of NGAL, IL-17, IL-6, IL-1β, TNF-α, and IFN-γ after paricalcitol administration ( p < 0.0001 ).
Conclusions.
25(OH)-vitamin D regulates immune and inflammatory processes.
Further studies are needed to confirm these data in order to improve the treatment of CKD patients.
American Psychological Association (APA)
Lucisano, Silvia& Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Montalto, Gaetano& Romeo, Adolfo…[et al.]. 2015. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
Modern Language Association (MLA)
Lucisano, Silvia…[et al.]. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
American Medical Association (AMA)
Lucisano, Silvia& Arena, Adriana& Stassi, Giovanna& Iannello, Daniela& Montalto, Gaetano& Romeo, Adolfo…[et al.]. Role of Paricalcitol in Modulating the Immune Response in Patients with Renal Disease. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065808