Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer
المؤلفون المشاركون
Gu, Yulu
Liu, Xiaoli
Yu, Yaqin
Shi, Jieping
Sun, Hui
Kanu, Joseph Sam
Liu, Yawen
Yu, Qiong
Zhang, Xin
Zhan, Siyan
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but the pathogenesis remains unclear.
rs2910164, located in pre-miR-146a, has been studied in PTCs with different ethnicity, but the results were inconsistent.
Here we evaluate the association between rs2910164 polymorphism and PTC and investigate the effect of this polymorphism on patients’ clinicopathological characteristics.
1238 PTC patients and 1275 controls, all Han population, from Northern China, were included in our study.
rs2910164 was genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS).
Analysis of inheritance model was performed using the SNPStats program.
Strength of association was assessed by odds ratio (OR) and 95% confidence interval (CI).
Overall, no statistical difference in rs2910164 genotype distribution and allelic frequencies between cases and controls was found, and patients with different genotypes had similar clinicopathological characteristics in terms of stage, location, concurrent of benign thyroid tumor, and thyroiditis, while, as the number of G alleles increased, proportion of patients aged ≥45 years and those without metastasis increased ( P trend < 0.001 and P trend = 0.003 , resp.).
However, no association remained significant after Bonferroni correction under any model of inheritance.
Our results suggest no association between rs2910164 polymorphism with PTC and patients’ clinicopathological characteristics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xin& Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Yu, Qiong…[et al.]. 2015. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xin…[et al.]. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xin& Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Yu, Qiong…[et al.]. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065816
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر