Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer
Joint Authors
Gu, Yulu
Liu, Xiaoli
Yu, Yaqin
Shi, Jieping
Sun, Hui
Kanu, Joseph Sam
Liu, Yawen
Yu, Qiong
Zhang, Xin
Zhan, Siyan
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence rate of papillary thyroid cancer (PTC) has increased over the past decades, but the pathogenesis remains unclear.
rs2910164, located in pre-miR-146a, has been studied in PTCs with different ethnicity, but the results were inconsistent.
Here we evaluate the association between rs2910164 polymorphism and PTC and investigate the effect of this polymorphism on patients’ clinicopathological characteristics.
1238 PTC patients and 1275 controls, all Han population, from Northern China, were included in our study.
rs2910164 was genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS).
Analysis of inheritance model was performed using the SNPStats program.
Strength of association was assessed by odds ratio (OR) and 95% confidence interval (CI).
Overall, no statistical difference in rs2910164 genotype distribution and allelic frequencies between cases and controls was found, and patients with different genotypes had similar clinicopathological characteristics in terms of stage, location, concurrent of benign thyroid tumor, and thyroiditis, while, as the number of G alleles increased, proportion of patients aged ≥45 years and those without metastasis increased ( P trend < 0.001 and P trend = 0.003 , resp.).
However, no association remained significant after Bonferroni correction under any model of inheritance.
Our results suggest no association between rs2910164 polymorphism with PTC and patients’ clinicopathological characteristics.
American Psychological Association (APA)
Zhang, Xin& Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Yu, Qiong…[et al.]. 2015. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
Modern Language Association (MLA)
Zhang, Xin…[et al.]. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
American Medical Association (AMA)
Zhang, Xin& Gu, Yulu& Liu, Xiaoli& Yu, Yaqin& Shi, Jieping& Yu, Qiong…[et al.]. Association of Pre-miR-146a rs2910164 Polymorphism with Papillary Thyroid Cancer. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065816