Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma
المؤلفون المشاركون
Ciliberto, Gennaro
Montella, Maurizio
Crispo, Anna
Capunzo, Mario
Nocerino, Flavia
Barbieri, Antonio
D’Ursi, Anna Maria
Tecce, Mario Felice
Amore, Alfonso
Galdiero, Massimiliano
Giudice, Aldo
D'Arena, Giovanni
Montella, Maurizio
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries.
Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females.
Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC.
While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels.
Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue.
This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections.
Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montella, Maurizio& D'Arena, Giovanni& Crispo, Anna& Capunzo, Mario& Nocerino, Flavia& Montella, Maurizio…[et al.]. 2015. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montella, Maurizio…[et al.]. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montella, Maurizio& D'Arena, Giovanni& Crispo, Anna& Capunzo, Mario& Nocerino, Flavia& Montella, Maurizio…[et al.]. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر