Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma
Joint Authors
Ciliberto, Gennaro
Montella, Maurizio
Crispo, Anna
Capunzo, Mario
Nocerino, Flavia
Barbieri, Antonio
D’Ursi, Anna Maria
Tecce, Mario Felice
Amore, Alfonso
Galdiero, Massimiliano
Giudice, Aldo
D'Arena, Giovanni
Montella, Maurizio
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries.
Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females.
Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC.
While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels.
Additionally, sex hormones can also affect HBV-related hepatocarcinogenesis by inducing epigenetic changes such as the regulation of mRNA levels by microRNAs (miRNAs), DNA methylation, and histone modification in liver tissue.
This review describes the molecular mechanisms underlying the gender disparity in HBV-related HCC with the aim of improving the understanding of key factors underneath the sex disparity often observed in HBV infections.
Furthermore, the review will propose more effective prevention strategies and treatments of HBV-derived diseases.
American Psychological Association (APA)
Montella, Maurizio& D'Arena, Giovanni& Crispo, Anna& Capunzo, Mario& Nocerino, Flavia& Montella, Maurizio…[et al.]. 2015. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
Modern Language Association (MLA)
Montella, Maurizio…[et al.]. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
American Medical Association (AMA)
Montella, Maurizio& D'Arena, Giovanni& Crispo, Anna& Capunzo, Mario& Nocerino, Flavia& Montella, Maurizio…[et al.]. Role of Sex Hormones in the Development and Progression of Hepatitis B Virus-Associated Hepatocellular Carcinoma. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1065832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065832