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Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy
المؤلفون المشاركون
Cruz Guzmán, Oriana del Rocío
Escobar Cedillo, Rosa Elena
López-Alarcón, Mardia
Bernabe García, Mariela
Coral-Vázquez, Ramón
Matute, Guadalupe
Velázquez Wong, Ana Claudia
Rodríguez-Cruz, Maricela
Sánchez, Raúl
المصدر
International Journal of Endocrinology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR.
Materials and Methods.
In 66 patients with DMD/BMD without corticosteroids treatment, IR, obesity, and body fat mass were evaluated.
Molecules involved in glucose metabolism were analyzed in muscle biopsies.
Results show that 18.3%, 22.7%, and 68% were underweight, overweight, or obese, and with high adiposity, respectively; 48.5% and 36.4% presented hyperinsulinemia and IR, respectively.
Underweight patients (27.3%) exhibited hyperinsulinemia and IR.
Carriers of deletions in exons 45 (OR = 9.32; 95% CI = 1.16–74.69) and 50 (OR = 8.73; 95% CI = 1.17–65.10) from DMD gene presented higher risk for IR than noncarriers.
We observed a greater staining of cytoplasmic aggregates for GLUT4 in muscle biopsies than healthy muscle tissue.
Conclusion.
Obesity, hyperinsulinemia, and IR were observed in DMD/BMD patients and are independent of corticosteroids treatment.
Carriers of deletion in exons 45 or 50 from DMD gene are at risk for developing IR.
It is suggested that alteration in GLUT4 in muscle fibers from DMD patients could be involved in IR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodríguez-Cruz, Maricela& Sánchez, Raúl& Escobar Cedillo, Rosa Elena& Cruz Guzmán, Oriana del Rocío& López-Alarcón, Mardia& Bernabe García, Mariela…[et al.]. 2015. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodríguez-Cruz, Maricela…[et al.]. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodríguez-Cruz, Maricela& Sánchez, Raúl& Escobar Cedillo, Rosa Elena& Cruz Guzmán, Oriana del Rocío& López-Alarcón, Mardia& Bernabe García, Mariela…[et al.]. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1065837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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