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Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy
Joint Authors
Cruz Guzmán, Oriana del Rocío
Escobar Cedillo, Rosa Elena
López-Alarcón, Mardia
Bernabe García, Mariela
Coral-Vázquez, Ramón
Matute, Guadalupe
Velázquez Wong, Ana Claudia
Rodríguez-Cruz, Maricela
Sánchez, Raúl
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Our aim was (1) to determine the frequency of insulin resistance (IR) in patients with Duchenne/Becker muscular dystrophy (DMD/BMD), (2) to identify deleted exons of DMD gene associated with obesity and IR, and (3) to explore some likely molecular mechanisms leading to IR.
Materials and Methods.
In 66 patients with DMD/BMD without corticosteroids treatment, IR, obesity, and body fat mass were evaluated.
Molecules involved in glucose metabolism were analyzed in muscle biopsies.
Results show that 18.3%, 22.7%, and 68% were underweight, overweight, or obese, and with high adiposity, respectively; 48.5% and 36.4% presented hyperinsulinemia and IR, respectively.
Underweight patients (27.3%) exhibited hyperinsulinemia and IR.
Carriers of deletions in exons 45 (OR = 9.32; 95% CI = 1.16–74.69) and 50 (OR = 8.73; 95% CI = 1.17–65.10) from DMD gene presented higher risk for IR than noncarriers.
We observed a greater staining of cytoplasmic aggregates for GLUT4 in muscle biopsies than healthy muscle tissue.
Conclusion.
Obesity, hyperinsulinemia, and IR were observed in DMD/BMD patients and are independent of corticosteroids treatment.
Carriers of deletion in exons 45 or 50 from DMD gene are at risk for developing IR.
It is suggested that alteration in GLUT4 in muscle fibers from DMD patients could be involved in IR.
American Psychological Association (APA)
Rodríguez-Cruz, Maricela& Sánchez, Raúl& Escobar Cedillo, Rosa Elena& Cruz Guzmán, Oriana del Rocío& López-Alarcón, Mardia& Bernabe García, Mariela…[et al.]. 2015. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
Modern Language Association (MLA)
Rodríguez-Cruz, Maricela…[et al.]. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
American Medical Association (AMA)
Rodríguez-Cruz, Maricela& Sánchez, Raúl& Escobar Cedillo, Rosa Elena& Cruz Guzmán, Oriana del Rocío& López-Alarcón, Mardia& Bernabe García, Mariela…[et al.]. Evidence of Insulin Resistance and Other Metabolic Alterations in Boys with Duchenne or Becker Muscular Dystrophy. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1065837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065837