Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature

المؤلفون المشاركون

Yang, Jun
Zhang, Jun
Xu, Qin
Sheng, Guo-ping
Weng, Wan-wen
Dong, Meng-jie

المصدر

International Journal of Endocrinology

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-04-28

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأحياء

الملخص EN

Context.

To report a patient with hyperthyroidism who developed concurrent occurrence of agranulocytosis and severe hepatotoxicity after taking methimazole (MMI).

Case.

A 51-year-old Chinese male was diagnosed as hyperthyroidism with normal white blood count and liver function.

After 4 weeks’ treatment with MMI 20 mg/d, it developed to agranulocytosis and severe cholestatic hepatotoxicity.

The patient’s symptoms and laboratory abnormalities disappeared after the withdrawal of MMI; his white blood count and liver function recover to normal in 2 weeks and 5 weeks, respectively.

296 MBq dose of 131I was given to the patient 3 weeks after the withdrawal of MMI and his thyroid function was back to normal in 6 months.

As we know through literature review, only 5 previous cases reported the synchronous ATD-induced agranulocytosis and severe hepatotoxicity in patients with hyperthyroidism.

Methods.

Review of the patient’s clinical course.

Literature review of cases of hyperthyroidism with agranulocytosis and severe hepatotoxicity demonstrated that these complications occurred after taking antithyroid drug (ATD).

Conclusions.

Patient with hyperthyroidism can have synchronous ATD-induced agranulocytosis and severe hepatotoxicity.

This case is extremely rare, but the adverse effects with ATDs is clinically significant.

The clinicians need to be careful about this and monitor biochemical of patients who take ATDs.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, Jun& Zhang, Jun& Xu, Qin& Sheng, Guo-ping& Weng, Wan-wen& Dong, Meng-jie. 2015. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065893

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, Jun…[et al.]. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065893

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, Jun& Zhang, Jun& Xu, Qin& Sheng, Guo-ping& Weng, Wan-wen& Dong, Meng-jie. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065893

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1065893