Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature
Joint Authors
Yang, Jun
Zhang, Jun
Xu, Qin
Sheng, Guo-ping
Weng, Wan-wen
Dong, Meng-jie
Source
International Journal of Endocrinology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Context.
To report a patient with hyperthyroidism who developed concurrent occurrence of agranulocytosis and severe hepatotoxicity after taking methimazole (MMI).
Case.
A 51-year-old Chinese male was diagnosed as hyperthyroidism with normal white blood count and liver function.
After 4 weeks’ treatment with MMI 20 mg/d, it developed to agranulocytosis and severe cholestatic hepatotoxicity.
The patient’s symptoms and laboratory abnormalities disappeared after the withdrawal of MMI; his white blood count and liver function recover to normal in 2 weeks and 5 weeks, respectively.
296 MBq dose of 131I was given to the patient 3 weeks after the withdrawal of MMI and his thyroid function was back to normal in 6 months.
As we know through literature review, only 5 previous cases reported the synchronous ATD-induced agranulocytosis and severe hepatotoxicity in patients with hyperthyroidism.
Methods.
Review of the patient’s clinical course.
Literature review of cases of hyperthyroidism with agranulocytosis and severe hepatotoxicity demonstrated that these complications occurred after taking antithyroid drug (ATD).
Conclusions.
Patient with hyperthyroidism can have synchronous ATD-induced agranulocytosis and severe hepatotoxicity.
This case is extremely rare, but the adverse effects with ATDs is clinically significant.
The clinicians need to be careful about this and monitor biochemical of patients who take ATDs.
American Psychological Association (APA)
Yang, Jun& Zhang, Jun& Xu, Qin& Sheng, Guo-ping& Weng, Wan-wen& Dong, Meng-jie. 2015. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065893
Modern Language Association (MLA)
Yang, Jun…[et al.]. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1065893
American Medical Association (AMA)
Yang, Jun& Zhang, Jun& Xu, Qin& Sheng, Guo-ping& Weng, Wan-wen& Dong, Meng-jie. Unusual Synchronous Methimazole-Induced Agranulocytosis and Severe Hepatotoxicity in Patient with Hyperthyroidism: A Case Report and Review of the Literature. International Journal of Endocrinology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1065893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1065893