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Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis
المؤلفون المشاركون
Padyukov, Leonid
Sandalov, Igor
المصدر
International Journal of Genomics
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
To identify putative relations between different genetic factors in the human genome in the development of common complex disease, we mapped the genetic data to an ensemble of spin chains and analysed the data as a quantum system.
Each SNP is considered as a spin with three states corresponding to possible genotypes.
The combined genotype represents a multispin state, described by the product of individual-spin states.
Each person is characterized by a single genetic vector (GV) and individuals with identical GVs comprise the GV group.
This consolidation of genotypes into GVs provides integration of multiple genetic variants for a single statistical test and excludes ambiguity of biological interpretation known for allele and haplotype associations.
We analyzed two independent cohorts, with 2633 rheumatoid arthritis cases and 2108 healthy controls, and data for 6 SNPs from the HTR2A locus plus shared epitope allele.
We found that GVs based on selected markers are highly informative and overlap for 98.3% of the healthy population between two cohorts.
Interestingly, some of the GV groups contain either only controls or only cases, thus demonstrating extreme susceptibility or protection features.
By using this new approach we confirmed previously detected univariateassociations and demonstrated the most efficient selection of SNPs for combined analyses for functional studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sandalov, Igor& Padyukov, Leonid. 2015. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sandalov, Igor& Padyukov, Leonid. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sandalov, Igor& Padyukov, Leonid. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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