Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis
Joint Authors
Padyukov, Leonid
Sandalov, Igor
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To identify putative relations between different genetic factors in the human genome in the development of common complex disease, we mapped the genetic data to an ensemble of spin chains and analysed the data as a quantum system.
Each SNP is considered as a spin with three states corresponding to possible genotypes.
The combined genotype represents a multispin state, described by the product of individual-spin states.
Each person is characterized by a single genetic vector (GV) and individuals with identical GVs comprise the GV group.
This consolidation of genotypes into GVs provides integration of multiple genetic variants for a single statistical test and excludes ambiguity of biological interpretation known for allele and haplotype associations.
We analyzed two independent cohorts, with 2633 rheumatoid arthritis cases and 2108 healthy controls, and data for 6 SNPs from the HTR2A locus plus shared epitope allele.
We found that GVs based on selected markers are highly informative and overlap for 98.3% of the healthy population between two cohorts.
Interestingly, some of the GV groups contain either only controls or only cases, thus demonstrating extreme susceptibility or protection features.
By using this new approach we confirmed previously detected univariateassociations and demonstrated the most efficient selection of SNPs for combined analyses for functional studies.
American Psychological Association (APA)
Sandalov, Igor& Padyukov, Leonid. 2015. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
Modern Language Association (MLA)
Sandalov, Igor& Padyukov, Leonid. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
American Medical Association (AMA)
Sandalov, Igor& Padyukov, Leonid. Genetic Vectors as a Tool in Association Studies: Definitions and Application for Study of Rheumatoid Arthritis. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066003