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Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data
المؤلفون المشاركون
Ignatieva, E. V.
Kolchanov, Nikolay
Levitsky, Victor G.
المصدر
International Journal of Genomics
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The expression level of each gene is controlled by its regulatory regions, which determine the precise regulation in a tissue-specific manner, according to the developmental stage of the body and the necessity of a response to external stimuli.
Nucleotide substitutions in regulatory gene regions may modify the affinity of transcription factors to their specific DNA binding sites, affecting the transcription rates of genes.
In our previous research, we found that genes controlling the sensory perception of smell and genes involved in antigen processing and presentation were overrepresented significantly among genes with high SNP contents in their promoter regions.
The goal of our study was to reveal functional features of human genes containing extremely small numbers of SNPs in promoter regions.
Two functional groups were found to be overrepresented among genes whose promoters did not contain SNPs: (1) genes involved in gene-specific transcription and (2) genes controlling chromatin organization.
We revealed that the 5′-regulatory regions of genes encoding transcription factors and chromatin-modifying proteins were characterized by reduced genetic variability.
One important exception from this rule refers to genes encoding transcription factors with zinc-coordinating DNA-binding domains (DBDs), which underwent extensive expansion in vertebrates, particularly, in primate evolution.
Hence, we obtained new evidence for evolutionary forces shaping variability in 5′-regulatory regions of genes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ignatieva, E. V.& Levitsky, Victor G.& Kolchanov, Nikolay. 2015. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ignatieva, E. V.…[et al.]. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ignatieva, E. V.& Levitsky, Victor G.& Kolchanov, Nikolay. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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