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Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data
Joint Authors
Ignatieva, E. V.
Kolchanov, Nikolay
Levitsky, Victor G.
Source
International Journal of Genomics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The expression level of each gene is controlled by its regulatory regions, which determine the precise regulation in a tissue-specific manner, according to the developmental stage of the body and the necessity of a response to external stimuli.
Nucleotide substitutions in regulatory gene regions may modify the affinity of transcription factors to their specific DNA binding sites, affecting the transcription rates of genes.
In our previous research, we found that genes controlling the sensory perception of smell and genes involved in antigen processing and presentation were overrepresented significantly among genes with high SNP contents in their promoter regions.
The goal of our study was to reveal functional features of human genes containing extremely small numbers of SNPs in promoter regions.
Two functional groups were found to be overrepresented among genes whose promoters did not contain SNPs: (1) genes involved in gene-specific transcription and (2) genes controlling chromatin organization.
We revealed that the 5′-regulatory regions of genes encoding transcription factors and chromatin-modifying proteins were characterized by reduced genetic variability.
One important exception from this rule refers to genes encoding transcription factors with zinc-coordinating DNA-binding domains (DBDs), which underwent extensive expansion in vertebrates, particularly, in primate evolution.
Hence, we obtained new evidence for evolutionary forces shaping variability in 5′-regulatory regions of genes.
American Psychological Association (APA)
Ignatieva, E. V.& Levitsky, Victor G.& Kolchanov, Nikolay. 2015. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
Modern Language Association (MLA)
Ignatieva, E. V.…[et al.]. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
American Medical Association (AMA)
Ignatieva, E. V.& Levitsky, Victor G.& Kolchanov, Nikolay. Human Genes Encoding Transcription Factors and Chromatin-Modifying Proteins Have Low Levels of Promoter Polymorphism: A Study of 1000 Genomes Project Data. International Journal of Genomics. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1066005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066005