Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis
المؤلفون المشاركون
Omar, Mahmoud
Abdel-Razek, Wael
Abo-Raia, Gamal
Assem, Medhat
El-Azab, Gasser
المصدر
International Journal of Hepatology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Serum cystatin C (CysC) was proposed as an effective reflection of the glomerular filtration rate (GFR).
However, its role in patients with liver cirrhosis has not been extensively verified especially in the detection of early RI.
Patients and Methods.
Seventy consecutive potential candidates for living donor liver transplantation with serum creatinine (Cr) <1.5 mg/dL were included.
CysC, Cr, and estimated GFR [creatinine clearance (CCr), Cockcroft-Gault formula (C-G), MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC] were all correlated to isotopic GFR.
Early RI was defined as GFR of 60–89 mL/min/1.73 m2.
Results.
Patients were 25.7% and 74.3% Child-Pugh classes B and C, respectively.
GFR was ≥90, 60–89, and 30–59 mL/min/1.73 m2 in 31.4%, 64.3%, and 4.3% of the patients, respectively.
All markers and equations, except C-G, were significantly correlated to GFR with CKD-EPI-Cr-CysC formula having the highest correlation (r = 0.474) and the largest area under the ROC curve (0.808) for discriminating early RI.
At a cutoff value of 1.2 mg/L, CysC was 89.6% sensitive and 63.6% specific in detecting early RI.
Conclusion.
In patients with liver cirrhosis, CysC and CysC-based equations showed the highest significant correlation to GFR and were measures that best discriminated early RI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Omar, Mahmoud& Abdel-Razek, Wael& Abo-Raia, Gamal& Assem, Medhat& El-Azab, Gasser. 2015. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Omar, Mahmoud…[et al.]. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Omar, Mahmoud& Abdel-Razek, Wael& Abo-Raia, Gamal& Assem, Medhat& El-Azab, Gasser. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر