Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis
Joint Authors
Omar, Mahmoud
Abdel-Razek, Wael
Abo-Raia, Gamal
Assem, Medhat
El-Azab, Gasser
Source
International Journal of Hepatology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Serum cystatin C (CysC) was proposed as an effective reflection of the glomerular filtration rate (GFR).
However, its role in patients with liver cirrhosis has not been extensively verified especially in the detection of early RI.
Patients and Methods.
Seventy consecutive potential candidates for living donor liver transplantation with serum creatinine (Cr) <1.5 mg/dL were included.
CysC, Cr, and estimated GFR [creatinine clearance (CCr), Cockcroft-Gault formula (C-G), MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC] were all correlated to isotopic GFR.
Early RI was defined as GFR of 60–89 mL/min/1.73 m2.
Results.
Patients were 25.7% and 74.3% Child-Pugh classes B and C, respectively.
GFR was ≥90, 60–89, and 30–59 mL/min/1.73 m2 in 31.4%, 64.3%, and 4.3% of the patients, respectively.
All markers and equations, except C-G, were significantly correlated to GFR with CKD-EPI-Cr-CysC formula having the highest correlation (r = 0.474) and the largest area under the ROC curve (0.808) for discriminating early RI.
At a cutoff value of 1.2 mg/L, CysC was 89.6% sensitive and 63.6% specific in detecting early RI.
Conclusion.
In patients with liver cirrhosis, CysC and CysC-based equations showed the highest significant correlation to GFR and were measures that best discriminated early RI.
American Psychological Association (APA)
Omar, Mahmoud& Abdel-Razek, Wael& Abo-Raia, Gamal& Assem, Medhat& El-Azab, Gasser. 2015. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
Modern Language Association (MLA)
Omar, Mahmoud…[et al.]. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
American Medical Association (AMA)
Omar, Mahmoud& Abdel-Razek, Wael& Abo-Raia, Gamal& Assem, Medhat& El-Azab, Gasser. Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis. International Journal of Hepatology. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066069