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Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?
المؤلفون المشاركون
Abo-Raia, Gamal
Khedr, Mohamed Ahmed
Sira, Ahmad Mohamed
Saber, Magdy Anwar
المصدر
International Journal of Hepatology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background & Aims.
The currently available treatment for chronic hepatitis C (CHC) in children is costly and with much toxicity.
So, predicting the likelihood of response before starting therapy is important.
Methods.
Serum adiponectin, vitamin D, and alpha-fetoprotein (AFP) were measured before starting pegylated-interferon/ribavirin therapy for 50 children with CHC.
Another 21 healthy children were recruited as controls.
Results.
Serum adiponectin, vitamin D, and AFP were higher in the CHC group than healthy controls (p<0.0001, p=0.071, and p=0.87, resp.).
In univariate analysis, serum adiponectin was significantly higher in responders than nonresponders (p<0.0001) and at a cutoff value ≥8.04 ng/mL it can predict treatment response by 77.8% sensitivity and 92.9% specificity, while both AFP and viremia were significantly lower in responders than nonresponders, p<0.0001 and p=0.0003, respectively, and at cutoff values ≤3.265 ng/mL and ≤235,384 IU/mL, respectively, they can predict treatment response with a sensitivity of 83.3% for both and specificity of 85.7% and 78.6%, respectively.
In multivariate analysis, adiponectin was found to be the only independent predictor of treatment response (p=0.044).
Conclusions.
The pretreatment serum level of adiponectin can predict the likelihood of treatment response, thus avoiding toxicities for those unlikely to respond to therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khedr, Mohamed Ahmed& Sira, Ahmad Mohamed& Saber, Magdy Anwar& Abo-Raia, Gamal. 2015. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khedr, Mohamed Ahmed…[et al.]. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khedr, Mohamed Ahmed& Sira, Ahmad Mohamed& Saber, Magdy Anwar& Abo-Raia, Gamal. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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