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Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?
Joint Authors
Abo-Raia, Gamal
Khedr, Mohamed Ahmed
Sira, Ahmad Mohamed
Saber, Magdy Anwar
Source
International Journal of Hepatology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background & Aims.
The currently available treatment for chronic hepatitis C (CHC) in children is costly and with much toxicity.
So, predicting the likelihood of response before starting therapy is important.
Methods.
Serum adiponectin, vitamin D, and alpha-fetoprotein (AFP) were measured before starting pegylated-interferon/ribavirin therapy for 50 children with CHC.
Another 21 healthy children were recruited as controls.
Results.
Serum adiponectin, vitamin D, and AFP were higher in the CHC group than healthy controls (p<0.0001, p=0.071, and p=0.87, resp.).
In univariate analysis, serum adiponectin was significantly higher in responders than nonresponders (p<0.0001) and at a cutoff value ≥8.04 ng/mL it can predict treatment response by 77.8% sensitivity and 92.9% specificity, while both AFP and viremia were significantly lower in responders than nonresponders, p<0.0001 and p=0.0003, respectively, and at cutoff values ≤3.265 ng/mL and ≤235,384 IU/mL, respectively, they can predict treatment response with a sensitivity of 83.3% for both and specificity of 85.7% and 78.6%, respectively.
In multivariate analysis, adiponectin was found to be the only independent predictor of treatment response (p=0.044).
Conclusions.
The pretreatment serum level of adiponectin can predict the likelihood of treatment response, thus avoiding toxicities for those unlikely to respond to therapy.
American Psychological Association (APA)
Khedr, Mohamed Ahmed& Sira, Ahmad Mohamed& Saber, Magdy Anwar& Abo-Raia, Gamal. 2015. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
Modern Language Association (MLA)
Khedr, Mohamed Ahmed…[et al.]. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
American Medical Association (AMA)
Khedr, Mohamed Ahmed& Sira, Ahmad Mohamed& Saber, Magdy Anwar& Abo-Raia, Gamal. Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?. International Journal of Hepatology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066074