CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence
المؤلفون المشاركون
Abrahamowicz, M.
Van Woudenberg, Mariel
Shin, Jean
Bernard, Manon
Syme, Catriona
Leonard, Gabriel
Perron, Michel
Richer, Louis
Veillette, Suzanna
Gaudet, Daniel
Paus, Tomas
Pausova, Zdenka
المصدر
International Journal of Hypertension
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Adolescents who exhibit exaggerated blood pressure (BP) reactivity to physical and mental challenges are at increased risk of developing hypertension in adulthood.
BP at rest and in response to challenges is higher in males than females, beginning in early adolescence.
CYP17A1 is one of the well-established gene loci of adult hypertension.
Here, we investigated whether this gene locus is associated with elevated BP at rest and in response to physical (active standing) and mental (math stress) challenges in adolescence.
We studied 496 male and 532 female adolescents (age 12–18 years) who were recruited from a genetic founder population.
Our results showed that the variant of CYP17A1 rs10786718 was associated with enhanced BP reactivity to the mental but not physical challenge and in males but not females.
In males, BP increase in response to math stress was higher in major versus minor allele homozygotes by 7.6 mm Hg (P=8.3×10-6).
Resting BP was not associated with the CYP17A1 variant in either sex.
These results suggest that, in adolescent males but not females, CYP17A1 enhances BP reactivity to mental stress.
Whether this effect contributes to the higher prevalence of hypertension in males than females later in life remains to be determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Van Woudenberg, Mariel& Shin, Jean& Bernard, Manon& Syme, Catriona& Abrahamowicz, M.& Leonard, Gabriel…[et al.]. 2015. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Van Woudenberg, Mariel…[et al.]. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Van Woudenberg, Mariel& Shin, Jean& Bernard, Manon& Syme, Catriona& Abrahamowicz, M.& Leonard, Gabriel…[et al.]. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر