CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence
Joint Authors
Abrahamowicz, M.
Van Woudenberg, Mariel
Shin, Jean
Bernard, Manon
Syme, Catriona
Leonard, Gabriel
Perron, Michel
Richer, Louis
Veillette, Suzanna
Gaudet, Daniel
Paus, Tomas
Pausova, Zdenka
Source
International Journal of Hypertension
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adolescents who exhibit exaggerated blood pressure (BP) reactivity to physical and mental challenges are at increased risk of developing hypertension in adulthood.
BP at rest and in response to challenges is higher in males than females, beginning in early adolescence.
CYP17A1 is one of the well-established gene loci of adult hypertension.
Here, we investigated whether this gene locus is associated with elevated BP at rest and in response to physical (active standing) and mental (math stress) challenges in adolescence.
We studied 496 male and 532 female adolescents (age 12–18 years) who were recruited from a genetic founder population.
Our results showed that the variant of CYP17A1 rs10786718 was associated with enhanced BP reactivity to the mental but not physical challenge and in males but not females.
In males, BP increase in response to math stress was higher in major versus minor allele homozygotes by 7.6 mm Hg (P=8.3×10-6).
Resting BP was not associated with the CYP17A1 variant in either sex.
These results suggest that, in adolescent males but not females, CYP17A1 enhances BP reactivity to mental stress.
Whether this effect contributes to the higher prevalence of hypertension in males than females later in life remains to be determined.
American Psychological Association (APA)
Van Woudenberg, Mariel& Shin, Jean& Bernard, Manon& Syme, Catriona& Abrahamowicz, M.& Leonard, Gabriel…[et al.]. 2015. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
Modern Language Association (MLA)
Van Woudenberg, Mariel…[et al.]. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
American Medical Association (AMA)
Van Woudenberg, Mariel& Shin, Jean& Bernard, Manon& Syme, Catriona& Abrahamowicz, M.& Leonard, Gabriel…[et al.]. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066127