Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis
المؤلفون المشاركون
Nee, Robert
Rivera, Ian
Little, Dustin J.
Yuan, Christina M.
Abbott, Kevin C.
المصدر
International Journal of Nephrology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background/Aims.
We aimed to examine the cost-effectiveness of mycophenolate mofetil (MMF) and azathioprine (AZA) as maintenance therapy for patients with Class III and Class IV lupus nephritis (LN), from a United States (US) perspective.
Methods.
Using a Markov model, we conducted a cost-utility analysis from a societal perspective over a lifetime horizon.
The modeled population comprised patients with proliferative LN who received maintenance therapy with MMF (2 gm/day) versus AZA (150 mg/day) for 3 years.
Risk estimates of clinical events were based on a Cochrane meta-analysis while costs and utilities were retrieved from other published sources.
Outcome measures included costs, quality-adjusted life-years (QALY), incremental cost-effectiveness ratios (ICER), and net monetary benefit.
Results.
The base-case model showed that, compared with AZA strategy, the ICER for MMF was $2,630,592/QALY at 3 years.
Over the patients’ lifetime, however, the ICER of MMF compared to AZA was $6,454/QALY.
Overall, the ICER results from various sensitivity and subgroup analyses did not alter the conclusions of the model simulation.
Conclusions.
In the short term, an AZA-based regimen confers greater value than MMF for the maintenance therapy of proliferative LN.
From a lifelong perspective, however, MMF is cost-effective compared to AZA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nee, Robert& Rivera, Ian& Little, Dustin J.& Yuan, Christina M.& Abbott, Kevin C.. 2015. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nee, Robert…[et al.]. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nee, Robert& Rivera, Ian& Little, Dustin J.& Yuan, Christina M.& Abbott, Kevin C.. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر