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Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis
Joint Authors
Nee, Robert
Rivera, Ian
Little, Dustin J.
Yuan, Christina M.
Abbott, Kevin C.
Source
International Journal of Nephrology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background/Aims.
We aimed to examine the cost-effectiveness of mycophenolate mofetil (MMF) and azathioprine (AZA) as maintenance therapy for patients with Class III and Class IV lupus nephritis (LN), from a United States (US) perspective.
Methods.
Using a Markov model, we conducted a cost-utility analysis from a societal perspective over a lifetime horizon.
The modeled population comprised patients with proliferative LN who received maintenance therapy with MMF (2 gm/day) versus AZA (150 mg/day) for 3 years.
Risk estimates of clinical events were based on a Cochrane meta-analysis while costs and utilities were retrieved from other published sources.
Outcome measures included costs, quality-adjusted life-years (QALY), incremental cost-effectiveness ratios (ICER), and net monetary benefit.
Results.
The base-case model showed that, compared with AZA strategy, the ICER for MMF was $2,630,592/QALY at 3 years.
Over the patients’ lifetime, however, the ICER of MMF compared to AZA was $6,454/QALY.
Overall, the ICER results from various sensitivity and subgroup analyses did not alter the conclusions of the model simulation.
Conclusions.
In the short term, an AZA-based regimen confers greater value than MMF for the maintenance therapy of proliferative LN.
From a lifelong perspective, however, MMF is cost-effective compared to AZA.
American Psychological Association (APA)
Nee, Robert& Rivera, Ian& Little, Dustin J.& Yuan, Christina M.& Abbott, Kevin C.. 2015. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
Modern Language Association (MLA)
Nee, Robert…[et al.]. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
American Medical Association (AMA)
Nee, Robert& Rivera, Ian& Little, Dustin J.& Yuan, Christina M.& Abbott, Kevin C.. Cost-Utility Analysis of Mycophenolate Mofetil versus Azathioprine Based Regimens for Maintenance Therapy of Proliferative Lupus Nephritis. International Journal of Nephrology. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1066243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066243