Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication
المؤلفون المشاركون
Atkinson, Helen C.
Marsh, Julie A.
Rath, Shoshana R.
Kotecha, Rishi S.
Gough, Hazel
Taylor, Mandy
Walwyn, Thomas
Gottardo, Nicholas G.
Cole, Catherine H.
Choong, Catherine S.
المصدر
International Journal of Pediatrics
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective & Design.
We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols (n=80) to determine longitudinal changes in body mass index (BMI) and the prevalence of obesity compared with a healthy reference population.
Results.
At diagnosis, the majority of patients (77.5%) were in the healthy weight category.
During treatment, increases in BMI z-scores were greater for females than males; the prevalence of obesity increased from 10.3% to 44.8% (P<0.004) for females but remained relatively unchanged for males (9.8% to 13.7%, P=0.7).
Longitudinal analysis using linear mixed-effects identified associations between BMI z-scores and time-dependent interactions with sex (P=0.0005), disease risk (P<0.0001), age (P=0.0001), and BMI z-score (P<0.0001) at diagnosis and total dose of steroid during maintenance (P=0.01).
Predicted mean BMI z-scores at the end of therapy were greater for females with standard risk ALL irrespective of age at diagnosis and for males younger than 4 years of age at diagnosis with standard risk ALL.
Conclusion.
Females treated on standard risk protocols and younger males may be at greatest risk of becoming obese during treatment for ALL.
These subgroups may benefit from intervention strategies to manage BMI during treatment for ALL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Atkinson, Helen C.& Marsh, Julie A.& Rath, Shoshana R.& Kotecha, Rishi S.& Gough, Hazel& Taylor, Mandy…[et al.]. 2015. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Atkinson, Helen C.…[et al.]. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Atkinson, Helen C.& Marsh, Julie A.& Rath, Shoshana R.& Kotecha, Rishi S.& Gough, Hazel& Taylor, Mandy…[et al.]. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر