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Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication
Joint Authors
Atkinson, Helen C.
Marsh, Julie A.
Rath, Shoshana R.
Kotecha, Rishi S.
Gough, Hazel
Taylor, Mandy
Walwyn, Thomas
Gottardo, Nicholas G.
Cole, Catherine H.
Choong, Catherine S.
Source
International Journal of Pediatrics
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective & Design.
We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols (n=80) to determine longitudinal changes in body mass index (BMI) and the prevalence of obesity compared with a healthy reference population.
Results.
At diagnosis, the majority of patients (77.5%) were in the healthy weight category.
During treatment, increases in BMI z-scores were greater for females than males; the prevalence of obesity increased from 10.3% to 44.8% (P<0.004) for females but remained relatively unchanged for males (9.8% to 13.7%, P=0.7).
Longitudinal analysis using linear mixed-effects identified associations between BMI z-scores and time-dependent interactions with sex (P=0.0005), disease risk (P<0.0001), age (P=0.0001), and BMI z-score (P<0.0001) at diagnosis and total dose of steroid during maintenance (P=0.01).
Predicted mean BMI z-scores at the end of therapy were greater for females with standard risk ALL irrespective of age at diagnosis and for males younger than 4 years of age at diagnosis with standard risk ALL.
Conclusion.
Females treated on standard risk protocols and younger males may be at greatest risk of becoming obese during treatment for ALL.
These subgroups may benefit from intervention strategies to manage BMI during treatment for ALL.
American Psychological Association (APA)
Atkinson, Helen C.& Marsh, Julie A.& Rath, Shoshana R.& Kotecha, Rishi S.& Gough, Hazel& Taylor, Mandy…[et al.]. 2015. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
Modern Language Association (MLA)
Atkinson, Helen C.…[et al.]. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
American Medical Association (AMA)
Atkinson, Helen C.& Marsh, Julie A.& Rath, Shoshana R.& Kotecha, Rishi S.& Gough, Hazel& Taylor, Mandy…[et al.]. Increased Body Mass Index during Therapy for Childhood Acute Lymphoblastic Leukemia: A Significant and Underestimated Complication. International Journal of Pediatrics. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1066696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066696