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Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy
المؤلفون المشاركون
Sosnowski, Tomasz
Jabłczyńska, Katarzyna
Janczewska, Magdalena
Kulikowska, Aleksandra
المصدر
International Journal of Polymer Science
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics.
Methods.
Nanostructures were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in the aqueous phase.
The resultant nanosuspensions of PAD (polyaldehyde dextran) and DACMC (dialdehyde carbomethylcellulose) were used as precursors in spray drying production of powders at variable process conditions.
The resultant dry microparticles were characterized by SEM observations, and their properties related to delivery by inhalation were determined by laser diffraction spectrometry following the dispersion in the commercial inhaler.
Finally, the possibility of the reconstitution of nanosuspensions by powders rehydration was evaluated.
Results.
Synthesized nanoparticles had size of 120–170 nm.
Microparticles after drying had size of 0.5–5 µm and different surface morphology.
Aerosolized particles obtained from powder dispersion in the inhaler had the volumetric median diameter of ~2 and ~1 µm for PAD and DACMC, respectively.
Hydration of powders led to restoring the nanosuspensions with the average particle size similar to the precursor.
Conclusions.
PAD and DACMC can be used to obtain nanostructures which, after processing, take a form suitable for effective delivery to the lungs via inhalation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jabłczyńska, Katarzyna& Janczewska, Magdalena& Kulikowska, Aleksandra& Sosnowski, Tomasz. 2015. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jabłczyńska, Katarzyna…[et al.]. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jabłczyńska, Katarzyna& Janczewska, Magdalena& Kulikowska, Aleksandra& Sosnowski, Tomasz. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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