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Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy
Joint Authors
Sosnowski, Tomasz
Jabłczyńska, Katarzyna
Janczewska, Magdalena
Kulikowska, Aleksandra
Source
International Journal of Polymer Science
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics.
Methods.
Nanostructures were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in the aqueous phase.
The resultant nanosuspensions of PAD (polyaldehyde dextran) and DACMC (dialdehyde carbomethylcellulose) were used as precursors in spray drying production of powders at variable process conditions.
The resultant dry microparticles were characterized by SEM observations, and their properties related to delivery by inhalation were determined by laser diffraction spectrometry following the dispersion in the commercial inhaler.
Finally, the possibility of the reconstitution of nanosuspensions by powders rehydration was evaluated.
Results.
Synthesized nanoparticles had size of 120–170 nm.
Microparticles after drying had size of 0.5–5 µm and different surface morphology.
Aerosolized particles obtained from powder dispersion in the inhaler had the volumetric median diameter of ~2 and ~1 µm for PAD and DACMC, respectively.
Hydration of powders led to restoring the nanosuspensions with the average particle size similar to the precursor.
Conclusions.
PAD and DACMC can be used to obtain nanostructures which, after processing, take a form suitable for effective delivery to the lungs via inhalation.
American Psychological Association (APA)
Jabłczyńska, Katarzyna& Janczewska, Magdalena& Kulikowska, Aleksandra& Sosnowski, Tomasz. 2015. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
Modern Language Association (MLA)
Jabłczyńska, Katarzyna…[et al.]. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
American Medical Association (AMA)
Jabłczyńska, Katarzyna& Janczewska, Magdalena& Kulikowska, Aleksandra& Sosnowski, Tomasz. Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy. International Journal of Polymer Science. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1066835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066835