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Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement
المؤلفون المشاركون
Feng, Xiugao
Xu, Xiangjin
Wang, Yue
Zheng, Zhiyong
Lin, Guiying
المصدر
International Journal of Rheumatology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases.
This study aims to investigate hip synovial tissues of ankylosing spondylitis (AS) patients for IgG4-positive plasma cells and ectopic lymphoid tissues with germinal centers (GCs).
Methods.
Synovial samples were collected from 7 AS patients who received total hip replacement and were evaluated using immunohistochemistry for the presence of CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic cells (FDC), and CD38+ plasma cells.
Furthermore, immunoglobulin G (IgG and IgG4), IgA, IgM, and complement components C3d and C4d in synovia were evaluated.
Both synovial CD21+ FDCs and IgG4-producing plasmacytes were analyzed.
Results.
All seven patients had severe fibrosis.
Massive infiltrations of lymphocytes were found in 5 out of 7 patients’ synovia.
Ectopic lymphoid tissues with CD21+ FDC networks and IgG4-positive plasma cells were observed coincidentally in two patients’ synovia.
Conclusion.
The pathophysiological mechanism of AS patients’ hip damage might be related to the coincidental presence of ectopic lymphoid tissue with FDCs network and IgG4-positive plasma cells identified here for the first time in AS patients’ inflamed synovial tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Feng, Xiugao& Xu, Xiangjin& Wang, Yue& Zheng, Zhiyong& Lin, Guiying. 2015. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Feng, Xiugao…[et al.]. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Feng, Xiugao& Xu, Xiangjin& Wang, Yue& Zheng, Zhiyong& Lin, Guiying. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066882
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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