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Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement
Joint Authors
Feng, Xiugao
Xu, Xiangjin
Wang, Yue
Zheng, Zhiyong
Lin, Guiying
Source
International Journal of Rheumatology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Ectopic lymphoid neogenesis and the presence of IgG4-positive plasmacytes have been confirmed in chronic inflammatory sclerosing diseases.
This study aims to investigate hip synovial tissues of ankylosing spondylitis (AS) patients for IgG4-positive plasma cells and ectopic lymphoid tissues with germinal centers (GCs).
Methods.
Synovial samples were collected from 7 AS patients who received total hip replacement and were evaluated using immunohistochemistry for the presence of CD20+ B-cells, CD3+ T-cells, CD21+ follicular dendritic cells (FDC), and CD38+ plasma cells.
Furthermore, immunoglobulin G (IgG and IgG4), IgA, IgM, and complement components C3d and C4d in synovia were evaluated.
Both synovial CD21+ FDCs and IgG4-producing plasmacytes were analyzed.
Results.
All seven patients had severe fibrosis.
Massive infiltrations of lymphocytes were found in 5 out of 7 patients’ synovia.
Ectopic lymphoid tissues with CD21+ FDC networks and IgG4-positive plasma cells were observed coincidentally in two patients’ synovia.
Conclusion.
The pathophysiological mechanism of AS patients’ hip damage might be related to the coincidental presence of ectopic lymphoid tissue with FDCs network and IgG4-positive plasma cells identified here for the first time in AS patients’ inflamed synovial tissue.
American Psychological Association (APA)
Feng, Xiugao& Xu, Xiangjin& Wang, Yue& Zheng, Zhiyong& Lin, Guiying. 2015. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
Modern Language Association (MLA)
Feng, Xiugao…[et al.]. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
American Medical Association (AMA)
Feng, Xiugao& Xu, Xiangjin& Wang, Yue& Zheng, Zhiyong& Lin, Guiying. Ectopic Germinal Centers and IgG4-Producing Plasmacytes Observed in Synovia of HLA-B27+ Ankylosing Spondylitis Patients with Advanced Hip Involvement. International Journal of Rheumatology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1066882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066882