Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer
المؤلفون المشاركون
Arnaout, Angel
Robertson, Susan
Kuchuk, Iryna
Simos, Demetrios
Pond, Gregory R.
Addison, Christina L.
Namazi, Mehrzad
Clemons, Mark
المصدر
International Journal of Surgical Oncology
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The waiting period to surgery represents a valuable “window of opportunity” to evaluate novel therapeutic strategies.
Interventional studies performed during this period require significant multidisciplinary collaboration to overcome logistical hurdles.
We undertook a one-year prospective window of opportunity study to assess feasibility.
Methods.
Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary surgery received anastrozole daily until surgery.
Feasibility was assessed by (a) the proportion of patients who consented and (b) completed the study.
Comparison of pre- and poststudy Ki67 labelling index and cleaved caspase 3 scores (CC3) was performed.
Results.
22/131 (16.8%) patients were confirmed eligible and 20/22 (91%) patients completed the study.
19/20 (95%) patients agreed to undergo optional additional tissue biopsies.
The mean duration of anastrozole use was 24.7 (15–44) days.
There were a statistically significant decline in mean Ki67 indices of 48.8% (p<0.001) and a trend towards significance in the decline of CC3 (p=0.17) when comparing pre- with posttreatment values.
Conclusion.
window of opportunity trials in breast cancer are a feasible way of assessing the biologic efficacy of different therapies in the presurgical setting.
The majority of eligible women were willing to participate including undergoing additional tissue biopsies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arnaout, Angel& Robertson, Susan& Kuchuk, Iryna& Simos, Demetrios& Pond, Gregory R.& Addison, Christina L.…[et al.]. 2015. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arnaout, Angel…[et al.]. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arnaout, Angel& Robertson, Susan& Kuchuk, Iryna& Simos, Demetrios& Pond, Gregory R.& Addison, Christina L.…[et al.]. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1066970
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر