Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer
Joint Authors
Arnaout, Angel
Robertson, Susan
Kuchuk, Iryna
Simos, Demetrios
Pond, Gregory R.
Addison, Christina L.
Namazi, Mehrzad
Clemons, Mark
Source
International Journal of Surgical Oncology
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The waiting period to surgery represents a valuable “window of opportunity” to evaluate novel therapeutic strategies.
Interventional studies performed during this period require significant multidisciplinary collaboration to overcome logistical hurdles.
We undertook a one-year prospective window of opportunity study to assess feasibility.
Methods.
Eligible newly diagnosed postmenopausal, estrogen receptor positive breast cancer patients awaiting primary surgery received anastrozole daily until surgery.
Feasibility was assessed by (a) the proportion of patients who consented and (b) completed the study.
Comparison of pre- and poststudy Ki67 labelling index and cleaved caspase 3 scores (CC3) was performed.
Results.
22/131 (16.8%) patients were confirmed eligible and 20/22 (91%) patients completed the study.
19/20 (95%) patients agreed to undergo optional additional tissue biopsies.
The mean duration of anastrozole use was 24.7 (15–44) days.
There were a statistically significant decline in mean Ki67 indices of 48.8% (p<0.001) and a trend towards significance in the decline of CC3 (p=0.17) when comparing pre- with posttreatment values.
Conclusion.
window of opportunity trials in breast cancer are a feasible way of assessing the biologic efficacy of different therapies in the presurgical setting.
The majority of eligible women were willing to participate including undergoing additional tissue biopsies.
American Psychological Association (APA)
Arnaout, Angel& Robertson, Susan& Kuchuk, Iryna& Simos, Demetrios& Pond, Gregory R.& Addison, Christina L.…[et al.]. 2015. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
Modern Language Association (MLA)
Arnaout, Angel…[et al.]. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
American Medical Association (AMA)
Arnaout, Angel& Robertson, Susan& Kuchuk, Iryna& Simos, Demetrios& Pond, Gregory R.& Addison, Christina L.…[et al.]. Evaluating the Feasibility of Performing Window of Opportunity Trials in Breast Cancer. International Journal of Surgical Oncology. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1066970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1066970