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A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency
المؤلفون المشاركون
Mendes, Jessica Bitencourt Emilio
Padilha de Paula, Josiane
Toledo, Maria da Graça
Pupo, Yasmine Mendes
Zanin, Sandra Maria Warumby
Farago, Paulo Vitor
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A simple stability-indicating HPLC-DAD method was validated for the determination of ferulic acid (FA) in polymeric microparticles.
Chromatographic conditions consisted of a RP C18 column (250 mm × 4.60 mm, 5 μm, 110 Å) using a mixture of methanol and water pH 3.0 (48 : 52 v/v) as mobile phase at a flow rate of 1.0 mL/min with UV detection at 320 nm.
The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of quantification, limit of detection, accuracy, precision, and robustness provided suitable results regarding all parameters investigated.
The calibration curve was linear in the concentration range of 10.0–70.0 μg/mL with a correlation coefficient >0.999.
Precision (intraday and interday) was demonstrated by a relative standard deviation lower than 2.0%.
Accuracy was assessed by the recovery test of FA from polymeric microparticles (99.02% to 100.73%).
Specificity showed no interference from the components of polymeric microparticles or from the degradation products derived from acidic, basic, and photolytic conditions.
In conclusion, the method is suitable to be applied to assay FA as bulk drug and into polymeric microparticles and can be used for studying its stability and degradation kinetics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. 2015. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mendes, Jessica Bitencourt Emilio…[et al.]. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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