A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency

Joint Authors

Mendes, Jessica Bitencourt Emilio
Padilha de Paula, Josiane
Toledo, Maria da Graça
Pupo, Yasmine Mendes
Zanin, Sandra Maria Warumby
Farago, Paulo Vitor

Source

Journal of Analytical Methods in Chemistry

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-13

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Chemistry

Abstract EN

A simple stability-indicating HPLC-DAD method was validated for the determination of ferulic acid (FA) in polymeric microparticles.

Chromatographic conditions consisted of a RP C18 column (250 mm × 4.60 mm, 5 μm, 110 Å) using a mixture of methanol and water pH 3.0 (48 : 52 v/v) as mobile phase at a flow rate of 1.0 mL/min with UV detection at 320 nm.

The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of quantification, limit of detection, accuracy, precision, and robustness provided suitable results regarding all parameters investigated.

The calibration curve was linear in the concentration range of 10.0–70.0 μg/mL with a correlation coefficient >0.999.

Precision (intraday and interday) was demonstrated by a relative standard deviation lower than 2.0%.

Accuracy was assessed by the recovery test of FA from polymeric microparticles (99.02% to 100.73%).

Specificity showed no interference from the components of polymeric microparticles or from the degradation products derived from acidic, basic, and photolytic conditions.

In conclusion, the method is suitable to be applied to assay FA as bulk drug and into polymeric microparticles and can be used for studying its stability and degradation kinetics.

American Psychological Association (APA)

Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. 2015. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181

Modern Language Association (MLA)

Mendes, Jessica Bitencourt Emilio…[et al.]. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067181

American Medical Association (AMA)

Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1067181