A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency
Joint Authors
Mendes, Jessica Bitencourt Emilio
Padilha de Paula, Josiane
Toledo, Maria da Graça
Pupo, Yasmine Mendes
Zanin, Sandra Maria Warumby
Farago, Paulo Vitor
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A simple stability-indicating HPLC-DAD method was validated for the determination of ferulic acid (FA) in polymeric microparticles.
Chromatographic conditions consisted of a RP C18 column (250 mm × 4.60 mm, 5 μm, 110 Å) using a mixture of methanol and water pH 3.0 (48 : 52 v/v) as mobile phase at a flow rate of 1.0 mL/min with UV detection at 320 nm.
The developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of quantification, limit of detection, accuracy, precision, and robustness provided suitable results regarding all parameters investigated.
The calibration curve was linear in the concentration range of 10.0–70.0 μg/mL with a correlation coefficient >0.999.
Precision (intraday and interday) was demonstrated by a relative standard deviation lower than 2.0%.
Accuracy was assessed by the recovery test of FA from polymeric microparticles (99.02% to 100.73%).
Specificity showed no interference from the components of polymeric microparticles or from the degradation products derived from acidic, basic, and photolytic conditions.
In conclusion, the method is suitable to be applied to assay FA as bulk drug and into polymeric microparticles and can be used for studying its stability and degradation kinetics.
American Psychological Association (APA)
Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. 2015. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
Modern Language Association (MLA)
Mendes, Jessica Bitencourt Emilio…[et al.]. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
American Medical Association (AMA)
Mendes, Jessica Bitencourt Emilio& Toledo, Maria da Graça& Pupo, Yasmine Mendes& Padilha de Paula, Josiane& Farago, Paulo Vitor& Zanin, Sandra Maria Warumby. A Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency. Journal of Analytical Methods in Chemistry. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067181
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067181