Inhibitory Effects of 4-(4-Methylbenzamino)‎benzoate on Adipocyte Differentiation

الملخص EN

The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds.

4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity.

In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism.

Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.