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Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes
المؤلفون المشاركون
Lee, Yun-Shien
Lin, Chia-Hung
Huang, Yu-Yao
Hsieh, Sheng-Hwu
Chen, Zih-Syuan
Tsai, Chi-Neu
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aim.
The relationship between genetic polymorphisms of the glucagon-like peptide-1 (GLP-1) receptor (GLP1R) gene and unresponsiveness to GLP-1 analogue treatment in patients with poorly controlled type 2 diabetes mellitus (DM) is unclear.
Methods.
Thirty-six patients with poorly controlled type 2 DM were enrolled and they received six days of continuous subcutaneous insulin infusion for this study.
After the normalization of blood glucose in the first 3 days, the patients then received a combination therapy with injections of the GLP-1 analogue, exenatide, for another 3 days.
All 13 exons and intron-exon boundaries of the GLP1R gene were amplified to investigate the association.
Results.
The short tandem repeat at 8GA/7GA (rs5875654) had complete linkage disequilibrium (LD, with r 2 = 1 ) with single nucleotide polymorphism (SNP) rs761386.
Quantitative trait loci analysis of GLP1R gene variation with clinical response of GLP1 analogue showed the missense rs3765467 and rs761386 significantly associated with changes in the standard deviation of plasma glucose ( SDP G baseline - SDP G treatment with GLP-1 analogue ) ( P = 0 .
041 and 0.019, resp.).
The reported P values became insignificant after multiple testing adjustments.
Conclusion.
The variable response to the GLP-1 analogue was not statistically correlated with polymorphisms of the GLP1R gene in patients with poorly controlled type 2 DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chia-Hung& Lee, Yun-Shien& Huang, Yu-Yao& Hsieh, Sheng-Hwu& Chen, Zih-Syuan& Tsai, Chi-Neu. 2015. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chia-Hung…[et al.]. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chia-Hung& Lee, Yun-Shien& Huang, Yu-Yao& Hsieh, Sheng-Hwu& Chen, Zih-Syuan& Tsai, Chi-Neu. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1067848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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