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Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes
Joint Authors
Lee, Yun-Shien
Lin, Chia-Hung
Huang, Yu-Yao
Hsieh, Sheng-Hwu
Chen, Zih-Syuan
Tsai, Chi-Neu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
The relationship between genetic polymorphisms of the glucagon-like peptide-1 (GLP-1) receptor (GLP1R) gene and unresponsiveness to GLP-1 analogue treatment in patients with poorly controlled type 2 diabetes mellitus (DM) is unclear.
Methods.
Thirty-six patients with poorly controlled type 2 DM were enrolled and they received six days of continuous subcutaneous insulin infusion for this study.
After the normalization of blood glucose in the first 3 days, the patients then received a combination therapy with injections of the GLP-1 analogue, exenatide, for another 3 days.
All 13 exons and intron-exon boundaries of the GLP1R gene were amplified to investigate the association.
Results.
The short tandem repeat at 8GA/7GA (rs5875654) had complete linkage disequilibrium (LD, with r 2 = 1 ) with single nucleotide polymorphism (SNP) rs761386.
Quantitative trait loci analysis of GLP1R gene variation with clinical response of GLP1 analogue showed the missense rs3765467 and rs761386 significantly associated with changes in the standard deviation of plasma glucose ( SDP G baseline - SDP G treatment with GLP-1 analogue ) ( P = 0 .
041 and 0.019, resp.).
The reported P values became insignificant after multiple testing adjustments.
Conclusion.
The variable response to the GLP-1 analogue was not statistically correlated with polymorphisms of the GLP1R gene in patients with poorly controlled type 2 DM.
American Psychological Association (APA)
Lin, Chia-Hung& Lee, Yun-Shien& Huang, Yu-Yao& Hsieh, Sheng-Hwu& Chen, Zih-Syuan& Tsai, Chi-Neu. 2015. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
Modern Language Association (MLA)
Lin, Chia-Hung…[et al.]. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
American Medical Association (AMA)
Lin, Chia-Hung& Lee, Yun-Shien& Huang, Yu-Yao& Hsieh, Sheng-Hwu& Chen, Zih-Syuan& Tsai, Chi-Neu. Polymorphisms of GLP-1 Receptor Gene and Response to GLP-1 Analogue in Patients with Poorly Controlled Type 2 Diabetes. Journal of Diabetes Research. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1067848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1067848